Exploiting the struggle for haem: a novel therapeutic approach against
نویسندگان
چکیده
Over the past decade, nontypeable Haemophilus influenzae (NTHi) has gained recognition as a major opportunistic pathogen of respiratory tract that imposes substantial global burden disease, owing to high rate morbidity and ensuing complications. Further amplifying impact NTHi infections is increasing spectrum prevalence antibiotic resistance, leading higher rates treatment failure with first- second-line antibiotics regimes. The threat resistance was recognised by World Health Organization in 2017, listing priority for which new therapies are urgently needed. Despite significant efforts, there currently no effective vaccine strategies available can slow growing disease. Consequently, alternative preventative or therapeutic approaches do not rely on susceptibility stable targets becoming more attractive. nutritional dependency haem at all stages pathogenesis exposes vulnerability may be exploited development such therapies. This article will discuss potential limit access this vital nutrient, particular focus novel bacteriotherapeutic approach under development.
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ژورنال
عنوان ژورنال: Microbiology Australia
سال: 2021
ISSN: ['1324-4272', '2201-9189']
DOI: https://doi.org/10.1071/ma21032